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pentobarbital will decrease the level or influence of abemaciclib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of abemaciclib with robust CYP3A4 inducers minimizes plasma focus of abemaciclib and its metabolites.Phenobarbital has become demonstrated to shorten the fifty percent-lifetime

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